Anouchka Coste Holt, DO

Dr. Coste completed her breast surgical oncology fellowship at the University of California Los Angeles, where she trained in providing personalized, evidence-based surgical care for breast cancer, benign breast disease, and high-risk patients. With advanced expertise in techniques such as hidden scar lumpectomies, nipple-sparing mastectomies, nipple delay, aesthetic flat closure, Goldilocks mastectomy and targeted axillary dissection. Dr. Coste is committed to achieving the best possible cosmetic outcomes for her patients while ensuring comprehensive oncologic care.

She is particularly focused on treating women with pathogenic mutations, triple-negative breast cancer, and oncoplastic surgery for breast conservation., Dr. Coste also has an interest in addressing healthcare disparities affecting Black and Hispanic women.

Her approach includes preventative measures with screening mammograms and breast ultrasound, as well as emphasizing the importance of exercise and stress relief.
As a Florida native, Dr. Coste graduated magna cum laude from the University of Central Florida. She continued her education at A.T. Still University School of Osteopathic
Medicine in Mesa, AZ where she graduated as a member of the Sigma Sigma Phi honor society. She completed her general surgery training at New York Medical College at
Wyckoff Heights Medical Center in Brooklyn, NY. During her residency, was awarded an NCI/NIH Ruth L. Kirschstein NRSA T32 Research Grant and completed a research fellowship in Surgical Oncology at Montefiore Albert Einstein College of Medicine in Bronx, NY. There she conducted in vivo research with a multi-photon microscope to study the expression of MenaInv and SOX-2 protein in the breast cancer tumor microenvironment.

Dr. Coste believes that continuing education and research are crucial to the improvement of breast care. She has authored several peer-reviewed articles on the tumor micro- environment in breast cancer and has presented on the topic of metastatic breast cancer at several national meetings for her research in breast cancer. She recently published on occult breast cancer and surgical outcomes in patients with triple negative breast cancer treated with immunotherapy and surgeon performed US-guided localization. Her clinical research interests include improving outcomes in underserved populations and those who receive neoadjuvant chemotherapy. She is an active member of various professional organizations and remains committed to advancing breast cancer through research and education. In her free time. Dr. Coste enjoys practicing vinyasa yoga and spending quality time with her family.

Publications:

Holt AC, Smith CA, Berkowitz MJ, Baker JL, McAndrew NP, Kapoor NS. Surgical outcomes following neoadjuvant chemotherapy with and without immunotherapy in patients with triple-negative breast cancer. Discov Oncol. 2024 Sep 20;15(1):467. doi: 10.1007/s12672-024-01349-7. PMID: 39302495; PMCID: PMC11415316.

Huy, Tess & Graham, Danielle & Baker, Jennifer & Thompson, Carlie & Smith, Courtney & Coste, Anouchka & Kapoor, Nimmi. (2024). Safety and Margin Positivity Rates of Surgeon-Performed Intraoperative Ultrasound-Guided Wire Localization for Breast Cancer. Surgical Oncology Insight. 1. 100057. 10.1016/j.soi.2024.100057.

Holt AC, Haji F, McCloskey S, Baker JL. De-escalation of surgery for occult breast cancer with axillary metastasis. Surgery. 2023 Aug;174(2):410-412. doi: 10.1016/j.surg.2023.03.020. Epub 2023 May 7. PMID: 37160408.

Borriello L, Coste A, Traub B, Sharma VP, Karagiannis GS, Lin Y, Wang Y, Ye X, Duran CL, Chen X, Friedman M, Sosa MS, Sun D, Dalla E, Singh DK, Oktay MH, Aguirre-Ghiso JA, Condeelis JS, Entenberg D. Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells. Nat Commun. 2022 Feb 2;13(1):626. doi: 10.1038/s41467-022-28076-3. PMID: 35110548; PMCID: PMC8811052.

Borriello L, Karagiannis GS, Duran CL, Coste A, Oktay MH, Entenberg D, Condeelis JS. The role of the tumor microenvironment in tumor cell intravasation and dissemination. Eur J Cell Biol. 2020 Aug;99(6):151098. doi: 10.1016/j.ejcb.2020.151098. Epub 2020 Jul 2. PMID: 32800278; PMCID: PMC7431678

Coste A , Karagiannis GS ,Wang Y , Xue E A , Lin Y , Skobe M , Jones JG , Oktay MH , Condeelis JS, Entenberg D. Hematogenous Dissemination of Breast Cancer Cells from Lymph Nodes is Mediated by Tumor MicroEnvironment of Metastasis (TMEM) Doorways Frontiers. 2020, Jun.

Tulla K, Caesar-Peterson S, Coste A, Wang J, Morrison N. Rare presentation of sepsis caused by necrotizing scalp infection. J Surg Case Rep. 2020 Mar;2020(3):rjaa024. doi: 10.1093/jscr/rjaa024. eCollection 2020 Mar. PubMed PMID: 32206295; PubMed Central PMCID: PMC7078591.

Coste A, Oktay MH, Condeelis JS, Entenberg D. Intravital Imaging Techniques for Biomedical and Clinical Research. Cytometry A. 2019 Dec 30;. doi: 10.1002/cyto.a.23963. [Epub ahead of print] Review. PubMed PMID: 31889408.

Karagiannis GS, Pastoriza JM, Borriello L, Jafari R, Coste A, Condeelis JS, Oktay MH, Entenberg D. Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis. J Vis Exp. 2019 Jun 26;(148). doi: 10.3791/59633. PubMed PMID: 31305525; PubMed Central PMCID: PMC6784529.

Kremen R, Casaubon J, Le CK, Dayal N, Coste A, Genelus-Dominique E, Carryl S. Evaluating Routine Upper Gastrointestinal Series after Laparoscopic Sleeve Gastrectomy. Am Surg. 2018 Nov 1;84(11):e461-e463. PubMed PMID: 30747652.

Coste AH, Shermetaro C. Cyst, Branchial Cleft.(2018) . StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. Available From http://www.ncbi.nlm.nih.gov/books/NBK499914/ PubMed PMID: 29763089.

Entenberg D., et al. (2017) Nature Methods Protocol. A Protocol for the Implantation of a Permanent Window for High-Resolution Imaging of the Murine Lung DOI: 10.1038/protex.2017.134

J.Ervil, A. Coste. (2011). Carbohydrate expression of pulmonary neoplasm as detected with periodic acid Schiff (PAS) reaction, Published in Florida Scientist, Quarterly Journal of the Florida Academy of Sciences Volume 74, Supp. 1. Florida Scientist , 74 (1), 84.